A newly identified macrophage manager ZEB2: still known as pivotal in early fetal development and cancer progression by driving the epithelial-to-mesenchymal transition.
Now proven as a master switch controlling the tumor-associated macrophage program
Fadi Sheban , Ido Amit et coll.
ZEB2 suppresses interferon response and antigen presentation in macrophages.
Targeting ZEB2 reprograms TAMs and induces anti-tumor immunity