A recent multicenter, randomized, double-blind, placebo-controlled study in 194 (full set analysis.
Generalized anxiety disorder-patients showed a significant decrease of -5 points in Hamilton Anxiety Rating Scale at day 28 with a single dose of 100 microgram of oral lysergide D-tartrate.
At this dose, lack of AE sets a very high bar for new therapies in this indication…
see: Robison et coll., JAMA.doi:10.1001/jama.2025.13481 Published online September4,2025.